Factor XIII cotreatment with hemostatic agents in hemophilia A increases fibrin α-chain crosslinking
نویسندگان
چکیده
منابع مشابه
Factor XIII in the treatment of hemophilia A.
n engl j med 366;3 nejm.org january 19, 2012 281 not match that of the patient. Tiede et al.2 observed that some patients with acquired hemophilia have been exposed to a factor VIII protein that does not match their own. Specifically, there are polymorphisms of factor VIII at amino acids 1241 (Asp→Glu) and 2004 (Glu→Lys). In patients with certain HLA-DRB1 alleles, exposure to a “foreign” factor...
متن کاملFibrin stabilization (factor XIII), fibrin structure and thrombosis.
Factor XIII (FXIII) is a zymogen that is converted into an active transglutaminase (FXIIIa) by the concerted action of thrombin and Ca2+. Its main task is to crosslink alpha-, and gamma-chains of fibrin and alpha2-plasmin inhibitor to fibrin. By this way FXIIIa strengthens fibrin and protects it from the prompt elimination by fibrinolytic system.The changes of FXIII level in thrombotic diseases...
متن کامل[Congenital deficiency of fibrin stabilizing factor [factor XIII)].
The authors report a new case of congenital deficiency of fibrin stabilizing factor. The defect is transmitted as an autosomal recessive trait. The earliest symptom is umbilical bleeding when the cord separates. The diagnosis is confirmed by the rapid dispersion of the clot in urea 5 M or monochloroacetic acid.
متن کاملRegulation of plasma factor XIII binding to fibrin in vitro.
The binding of plasma factor XIII to fibrinogen or fibrin that has been chemically or enzymatically induced to polymerize was studied. Factor XIII binding was assayed using a 3H-putrescine incorporation assay and an 125I-plasma factor XIII binding assay. More than 80% of the native and radiolabeled plasma factor XIII was bound to fibrin I formed by reptilase in EDTA, citrate, or heparin anticoa...
متن کاملFibrin cross-linking in congenital factor XIII deficiency.
Homozygous patients with factor XIII deficiency are devoid of immunologically identifiable A protein, the active enzymatic component. Quantitative studies of transamidase activity of the factor are available in only a few cases, and the fibrin cross-linking pattern is not well known. The present paper deals with the quantitative estimation of factor XIII transamidase activity (dansylcadaverine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2017
ISSN: 1538-7933
DOI: 10.1111/jth.13887